Preclinical Toxicology Services

Adita Biosys offers a comprehensive range of preclinical toxicology services to deliver thorough safety assessments and support your research and development needs. 

  • Toxicology studies
  • Microbiology and Genotoxicity studies
  • Efficacy studies
  • Biocompatibility studies
  • Immunization studies/Antibody production
  • Bioassays/pharmacopeia studies (USP, BP, EP, IP)

Biocompatibility Studies for Medical Devices

  • Cytotoxicity
  • Skin Sensitization
  • Irritation / Intracutaneous
  • Systemic Toxicity
  • Genetic Toxicity
  • Implantation Studies (Muscle / Subcutenous / Bone)
  • Haemocompatibility Test
  • USP Class VI test

Acute Toxicity

  • Acute Oral / Dermal / IV / IM / SC / IP / Ocular
  • Acute Inhalation
  • Acute Dermal Irritation / Corrosion
  • Acute Eye Irritation / Corrosion
  • Acute Infusion Studies
  • Skin Sensitization Studies
  • Acute Neuro Toxicity Study in Rats

Sub‑Acute Toxicity

  • 7 / 14 Days Dose Range Finding Studies
  • 14 / 28 Days Repeated Dose Studies

Sub‑Chronic & Chronic Toxicity

  • 90 Days Repeated Dose Studies
  • 180 Days & above Chronic Toxicity Studies

Genetic Toxicity

  • Bacterial Reverse Mutation Test (AMES Test)
  • In vitro Chromosome Aberration Test
  • In vitro Mammalian Cell Micronucleus Test
  • Mouse Lymphoma Assay
  • In vivo Chromosome Aberration Test
  • In vivo mammalian erythrocyte micronucleus test
  • HPRT
  • Microbiology

Bioassays

  • Menotropin FSH / LH Activity
  • Human Chorionic Gonadotropin
  • Estrogenic Activity
  • Follitropin, Residual LH Activity
  • Erythropoietin (EPO)
  • Insulin Assays Rabbit Pyrogen Testing
  • Endotoxin Testing
  • Abnormal Toxicity Sterility Tests
  • Test for Microbial Contamination
  • Microbiological Assay of Antibiotics
  • Efficacy of Antimicrobial Preservation

Immunization Studies

  • Polyclonal antibody production in Rats / Mice / Rabbits & Guinea Pigs

Efficacy Studies

  • Diet Induced Obesity Studies
  • Chemical Induced Obesity Studies
  • Inflammation Studies
  • Anti‑Diabetic Studies
  • Preservative Efficacy Test
  • Wound Healing Studies
  • PK Studies (In‑life Phase)
  • Glucose Tolerance Test (GTT)
  • Avian Oral Toxicity Study

Chemistry Services

  • Analytical Method Development & Validation
  • Analytical Services to Support Toxicological Studies (e.g., Solubility, Homogeneity, Stability, Dose Concentration)
  • Physical State
  • Color
  • Odor
  • pH
  • Density
  • Determination of Chemical Incompatibility
  • Miscibility in Water, Organic Solvent, Hydrocarbon Oil

Routes of Administration

  • Oral
  • Intravenous
  • Ocular
  • Dermal
  • Inhalation
  • Intradermal
  • Intramuscular
  • Intranasal
  • Subcutaneous
  • Intraocular
  • Intracorneal
  • Infusion
  • Intravitreal
  • Intraperitoneal